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Methylation of p53 protein by KMT7/SET7 is the primary reported KMT-mediated methylation event on a non-histone protein 18 Since that discovery, several KMTs, as well as KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making p53 essentially the most extensively studied non-histone protein present process lysine methylation 4 , thirteen , 16 , 18 , 162 Here we use p53 as a mannequin to discuss the capabilities of lysine methylation of non-histone proteins.

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